Sumayia Al-Anazi; Isra Al-Turaiki; Najwa Altwaijry
Abstract
Motif discovery is a challenging problem in bioinformatics. It is an essential step towards understanding gene regulation. Although numerous algorithms and tools have been proposed in the literature, the accuracy of motif finding is still low. In this paper, we tackle the motif discovery problem using ...
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Motif discovery is a challenging problem in bioinformatics. It is an essential step towards understanding gene regulation. Although numerous algorithms and tools have been proposed in the literature, the accuracy of motif finding is still low. In this paper, we tackle the motif discovery problem using ensemble methods. A review and classification of current ensemble motif discovery tools is presented. We then propose our Cluster-based Ensemble Motif Discovery Tool (CEMD) which is based on k-medoids clustering of state-of-art stand-alone motif finding tools. We evaluate the performance of CEMD on benchmark datasets and compare the results to both stand-alone and similar ensemble tools. Experimental results indicate that CEMD has better sensitivity than state-of-art stand-alone tools when dealing with human datasets. CEMD also obtains better values of sensitivity when motifs are implanted in real promoter sequences. As for the comparison of CEMD with ensemble motif discovery tools, results indicate that CEMD achieves better results than MEME-ChIP on all evaluation measures. CEMD shows comparable performance to RSAT peak-motifs and MODSIDE.
Mustapha Bassiri; Abderrazak Mazouak; Imad Lamniai; Malika Tridane; Said Belaaouad; Said Belaaouad
Abstract
The application of New Information and Communication Technologies (NICT) in the field of training led to the creation of this new reality called distance learning. Described as the marriage of multimedia (sound, image, text) and the Internet (online distribution, interactivity) DT has no doubt allowed ...
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The application of New Information and Communication Technologies (NICT) in the field of training led to the creation of this new reality called distance learning. Described as the marriage of multimedia (sound, image, text) and the Internet (online distribution, interactivity) DT has no doubt allowed to revive pedagogies to a new digital without or less presence. Our purpose is to verify the impact of open distance learning on the development of socio-professional skills among future administrators of the Ministry of National Education in initial training. In addition, the instrumentation of these training devices also provides a framework for evaluating, monitoring and controlling the training process, using the resources of computers and the Internet. Our research context takes place at the level of TAZA Regional Center of Trades Education and Training (CRMEF) during the academic year 2016-2017, the use of technological tools by trainers or trainees is quite common in courses, parallel activities, self-training, communication trainers-trainees or trainee-counsellors but all these forms suffer from the absence of a general frame of reference and regulation which guides the training actions via these tools. Indeed, the recommended methodology based on engineering training devices and skills in a virtual environment ie ” The technical instrumentation “and” educational scripting ” objects and training content. During its creation as its implementation, our platform experienced several difficulties including technical. Or today seeing the results of the questionnaires and following the feedbacks of trainee administrators we can judge that our goal is achieved.